PHARMACEUTICS

Roles of rhamnolipids in pharmaceutics: medicine carrier, medicine booster and activator for the immune system and in other biological processes.

Uses in Medicine:

Based on the properties of rhamnolipids and the mechanism of their action on cells, they can be used in medicine in the following areas:

• Treatment of wounds, including chronic ulcer, bedsores, burns (including radioactive burns)
• To enhance the effect of antibiotics in the treatment of infections
• As oral agents for improving the absorption of various drugs.
• Use in re-epithelialization of mucous membranes, especially for the healing of the mucous membranes, in the treatment and prevention of gum diseases such as gingivitis and periodontal regeneration.
• Treatment of autoimmune diseases. The treatment will be in organ-specific autoimmune diseases and also in non-organ specific autoimmune diseases psoriasis, lichen planus, lupus erythematosus, ichthyosis, AIDS, Alzheimer's disease, Parkinson's disease and Amyotrophic Lateral Sclerosis (ALS)
• Treatment of dermatological diseases
• The treatment of diseases associated with obesity: the metabolic syndrome, arterial hypertension, type 2 diabetes, nonalcoholic fatty liver disease or obesity-related obesity
• Treatment of rhinitis and sinusitis
• Create based on rhamnolipid liposomes for use as microcapsules for drugs, proteins, nucleic acids, dyes and other compounds. Rhamnolipid liposomes have an affinity for biological tissues, are non-toxic and biodegradable, with long lifetimes.

The mechanism of action of rhamnolipids in pharmaceutical preparations

• Stimulating the production in the bone marrow of neutrophils and monocytes responsible for humoral immunity;
• Possessing the immunosuppressive activity to T lymphocytes (treatment of autoimmune diseases);
• The inhibition of a number of enzymes (treatment of autoimmune diseases);
• Antiproliferative activity
• Stimulating the proliferation of keratinocytes involved in the healing process (reepithelialization) of the wounds;
• Reducing fibrosis in wound healing;
• Rhamnolipids in pharmaceutical preparations for oral use increase the permeability of cell membranes, resulting in better absorption of drugs;
• Rhamnolipids reduce the level of cytokines (in vivo);
• Treatment of conditions associated with obesity. Rhamnolipids affect the level of triglycerides, creatinine, alanine transaminaza, reduces blood sugar levels.